Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Cytosolic carboxylases translocate to mitochondrial matrix

hCBXs → hCBXs

Reactome: R-HSA-3323111
Compartment: cytosol · mitochondrial matrix
Rhea: None recorded

Inputs

hCBXsR-HSA-3323101, cytosol

Outputs

hCBXsR-HSA-3065950, mitochondrial matrix

Literature

Holocarboxylase synthetase: correlation of protein localisation with biological function Arch. Biochem. Biophys., 2010
Identification of holocarboxylase synthetase (HCS) proteins in human placenta Biochim. Biophys. Acta, 1998
Selectivity in post-translational biotin addition to five human carboxylases J. Biol. Chem., 2012