Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1

8 UDP-Glc + oligoGlc-GYG1:GYS1-b tetramer → 8 UDP + polyGlc-GYG1:GYS1-b tetramer + 8 H+

Reactome

R-HSA-3322041

Compartment

cytosol

Rhea

RHEA:18550

Catalysed by

• alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity of oligoGlc-GYG1:GYS1-b tetramer [cytosol]EC 2.4.1.11

Literature

1. Identification of a novel mutation in GYS1 (muscle-specific glycogen synthase) resulting in sudden cardiac death, that is diagnosable from skin fibroblasts Mol. Genet. Metab., 2009
2. Glycogen and its metabolism: some new developments and old themes Biochem. J., 2012