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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a

polyGlc-GYG1:GYS1-a tetramer → glycogen-GYG1:GYS1-a tetramer

Reactome: R-HSA-3322005
Compartment: cytosol
Rhea: None recorded

Inputs

polyGlc-GYG1:GYS1-a tetramerR-HSA-3322054, cytosol

Outputs

glycogen-GYG1:GYS1-a tetramerR-HSA-3322059, cytosol

Catalysed by

1,4-alpha-glucan branching enzyme activity of GBE1 [cytosol]EC 2.4.1.18; UniProt Q04446

Literature

Hepatic and neuromuscular forms of glycogen storage disease type IV caused by mutations in the same glycogen-branching enzyme gene. J Clin Invest, 1996
Glycogen and its metabolism: some new developments and old themes Biochem. J., 2012