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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR

MTRR:MTR + MMACHC:MMADHC:cob(II)alamin → MTRR:MTR:cob(II)alamin + MMACHC + MMADHC

Reactome: R-HSA-3204318
Compartment: cytosol
Rhea: None recorded

Inputs

MTRR:MTRR-HSA-3204322, cytosol
MMACHC:MMADHC:cob(II)alaminR-HSA-3149533, cytosol

Outputs

MTRR:MTR:cob(II)alaminR-HSA-3149544, cytosol
MMACHCR-HSA-2980949, cytosol
MMADHCR-HSA-3149529, cytosol

Catalysed by

molecular carrier activity of MTRR:MTR [cytosol]

Literature

Redox-Linked Coordination Chemistry Directs Vitamin B 12 Trafficking Acc Chem Res, 2021
Structural features of recombinant MMADHC isoforms and their interactions with MMACHC, proteins of mammalian vitamin B12 metabolism Mol. Genet. Metab., 2012
Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B(12) metabolism Mol. Genet. Metab., 2013
Interaction between MMACHC and MMADHC, two human proteins participating in intracellular vitamin B?? metabolism Mol. Genet. Metab., 2011
Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase-methionine synthase reductase complex FEBS J., 2009
Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry Biochemistry, 2007