Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AOX1 oxidises PXL to PDXate

H2O + O2 + PXL → PDXate + H2O2

Reactome: R-HSA-3204311
Compartment: cytosol
Rhea: RHEA:23725

Inputs

H2OCHEBI:15377, H2O, cytosol
O2CHEBI:15379, O2, cytosol
PXLCHEBI:17310, C8H9NO3, cytosol

Outputs

PDXateCHEBI:30959, C8H8NO4, cytosol
H2O2CHEBI:16240, H2O2, cytosol

Catalysed by

aldehyde oxidase activity of 2xAOX1:cofactors [cytosol]EC 1.2.3.1

Literature

The impact of single nucleotide polymorphisms on human aldehyde oxidase Drug Metab. Dispos., 2012