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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC52A1,2,3 transport RIB from extracellular region to cytosol

RIB → RIB

Reactome: R-HSA-3165230
Compartment: cytosol · extracellular region · plasma membrane
Rhea: RHEA:35015

Inputs

RIBCHEBI:57986, C17H19N4O6, extracellular region

Outputs

RIBCHEBI:57986, C17H19N4O6, cytosol

Catalysed by

riboflavin transmembrane transporter activity of SLC52A1,2,3 [plasma membrane]

Literature

Identification and comparative functional characterization of a new human riboflavin transporter hRFT3 expressed in the brain J. Nutr., 2010
Brown-Vialetto-Van Laere syndrome, a ponto-bulbar palsy with deafness, is caused by mutations in c20orf54 Am. J. Hum. Genet., 2010
Brown-Vialetto-Van Laere and Fazio Londe syndrome is associated with a riboflavin transporter defect mimicking mild MADD: a new inborn error of metabolism with potential treatment J. Inherit. Metab. Dis., 2011
Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1 Am. J. Physiol., Cell Physiol., 2008
Functional involvement of RFVT3/SLC52A3 in intestinal riboflavin absorption Am. J. Physiol. Gastrointest. Liver Physiol., 2014