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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MMAA:MUT binds AdoCbl

2xMMAA:2xMUT + AdoCbl → 2xMMAA:2xMUT:AdoCbl

Reactome: R-HSA-3159259
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

2xMMAA:2xMUTR-HSA-3159295, mitochondrial matrix
AdoCblCHEBI:18408, C72H100CoN18O17P, mitochondrial matrix

Outputs

2xMMAA:2xMUT:AdoCblR-HSA-3159272, mitochondrial matrix

Catalysed by

molecular carrier activity of 2xMMAA:2xMUT [mitochondrial matrix]

Literature

Cloning of full-length methylmalonyl-CoA mutase from a cDNA library using the polymerase chain reaction Genomics, 1989
Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements Proc. Natl. Acad. Sci. U.S.A., 2002
Spectrum of mutations in mut methylmalonic acidemia and identification of a common Hispanic mutation and haplotype Hum. Mutat., 2006
Mutations in the MMAA gene in patients with the cblA disorder of vitamin B12 metabolism Hum. Mutat., 2004