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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MMADHC targets transport of cytosolic cob(II)alamin to mitochondria

MMACHC:MMADHC:cob(II)alamin → cob(II)alamin + MMADHC + MMACHC

Reactome: R-HSA-3149563
Compartment: cytosol · mitochondrial matrix
Rhea: None recorded

Inputs

MMACHC:MMADHC:cob(II)alaminR-HSA-3149533, cytosol

Outputs

cob(II)alaminCHEBI:16304, C62H88CoN13O14P, mitochondrial matrix
MMADHCR-HSA-3149529, cytosol
MMACHCR-HSA-2980949, cytosol

Catalysed by

molecular carrier activity of MMACHC:MMADHC:cob(II)alamin [cytosol]

Literature

Redox-Linked Coordination Chemistry Directs Vitamin B 12 Trafficking Acc Chem Res, 2021
Gene identification for the cblD defect of vitamin B12 metabolism N. Engl. J. Med., 2008
Molecular mechanisms leading to three different phenotypes in the cblD defect of intracellular cobalamin metabolism Hum. Mol. Genet., 2012