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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MMACHC decyanates CNCbl

2 CNCbl + NADPH + H+ + 2 MMACHC → 2 MMACHC:cob(II)alamin + 2 HCN + NADP+

Reactome: R-HSA-3149519
Compartment: cytosol
Rhea: RHEA:16115

Inputs

2 CNCblCHEBI:17439, C63H88CoN14O14P, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol
2 MMACHCR-HSA-2980949, cytosol

Outputs

2 MMACHC:cob(II)alaminR-HSA-3095903, cytosol
2 HCNCHEBI:18407, CHN, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

cyanocobalamin reductase (cyanide-eliminating) (NADP+) activity of MMACHC [cytosol]EC 1.16.1.6; UniProt Q9Y4U1

Literature

Decyanation of vitamin B12 by a trafficking chaperone Proc. Natl. Acad. Sci. U.S.A., 2008
Structural basis of multifunctionality in a vitamin B12-processing enzyme J Biol Chem, 2011
Vitamin B12: unique metalorganic compounds and the most complex vitamins Molecules, 2010