MTRR reduces cob(II)alamin to meCbl
2 MTRR:MTR:cob(II)alamin + NADPH + 2 AdoMet → 2 MTRR:MTR:MeCbl + 2 AdoHcy + NADP+ + H+
- Reactome
- R-HSA-3149518
- Compartment
- cytosol
- Rhea
- RHEA:23910
Inputs
- 2 MTRR:MTR:cob(II)alaminR-HSA-3149544, cytosol
- NADPHCHEBI:57783, C21H26N7O17P3, cytosol
- 2 AdoMetCHEBI:59789, C15H23N6O5S, cytosol
Outputs
- 2 MTRR:MTR:MeCblR-HSA-3149551, cytosol
- 2 AdoHcyCHEBI:57856, C14H20N6O5S, cytosol
- NADP+CHEBI:58349, C21H25N7O17P3, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- [methionine synthase] reductase (NADPH) activity of MTRR:MTR:cob(II)alamin [cytosol]EC 1.16.1.8
Literature
- Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida Am. J. Hum. Genet., 2002
- Interaction of flavodoxin with cobalamin-dependent methionine synthase Biochemistry, 2000
- A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida Mol. Genet. Metab., 1999
- Molecular basis for methionine synthase reductase deficiency in patients belonging to the cblE complementation group of disorders in folate/cobalamin metabolism Hum. Mol. Genet., 1999
- Cobalamin uptake and reactivation occurs through specific protein interactions in the methionine synthase-methionine synthase reductase complex FEBS J., 2009
- Mechanism of coenzyme binding to human methionine synthase reductase revealed through the crystal structure of the FNR-like module and isothermal titration calorimetry Biochemistry, 2007