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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MMACHC:cob(II)alamin binds MMADHC

MMACHC:cob(II)alamin + MMADHC → MMACHC:MMADHC:cob(II)alamin

Reactome: R-HSA-3149494
Compartment: cytosol
Rhea: None recorded

Inputs

MMACHC:cob(II)alaminR-HSA-3095903, cytosol
MMADHCR-HSA-3149529, cytosol

Outputs

MMACHC:MMADHC:cob(II)alaminR-HSA-3149533, cytosol

Catalysed by

molecular carrier activity of MMADHC [cytosol]UniProt Q9H3L0

Literature

Redox-Linked Coordination Chemistry Directs Vitamin B 12 Trafficking Acc Chem Res, 2021
Subcellular location of MMACHC and MMADHC, two human proteins central to intracellular vitamin B(12) metabolism Mol. Genet. Metab., 2013
Interaction between MMACHC and MMADHC, two human proteins participating in intracellular vitamin B?? metabolism Mol. Genet. Metab., 2011
Structural features of recombinant MMADHC isoforms and their interactions with MMACHC, proteins of mammalian vitamin B12 metabolism Mol. Genet. Metab., 2012
Gene identification for the cblD defect of vitamin B12 metabolism N. Engl. J. Med., 2008