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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

TCN1 binds RCbl

TCN1 + dietary protein:RCbl → TCN1:RCbl + dietary protein

Reactome: R-HSA-3132759
Compartment: extracellular region
Rhea: None recorded

Inputs

TCN1R-HSA-2980920, extracellular region
dietary protein:RCblR-ALL-3132775, extracellular region

Outputs

TCN1:RCblR-HSA-3132765, extracellular region
dietary proteinR-ALL-8984753, extracellular region

Catalysed by

cargo receptor ligand activity of TCN1 [extracellular region]UniProt P20061

Literature

Haptocorrin in humans Clin Chem Lab Med, 2007
Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway Nat Rev Gastroenterol Hepatol, 2012
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues Mol Syst Biol, 2019