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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Pancreatic proteases degrade TCN1:RCbl

TCN1:RCbl → RCbl

Reactome: R-HSA-3132753
Compartment: extracellular region
Rhea: None recorded

Inputs

TCN1:RCblR-HSA-3132765, extracellular region

Outputs

RCblCHEBI:140785, C62H88CoN13O14PR, extracellular region

Catalysed by

serine-type peptidase activity of PRSS1,3,CTRB1,2 [extracellular region]

Literature

Effect of gastrointestinal proteases on purified human intrinsic factor-vitamin B12 (IF-B12) complex Indian J. Biochem. Biophys., 2003
Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway Nat Rev Gastroenterol Hepatol, 2012