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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ABCC1 transports cytosolic RCbl to extracellular region

ATP + H2O + RCbl → ADP + Pi + RCbl

Reactome: R-HSA-3095901
Compartment: cytosol · lysosomal lumen · lysosomal membrane
Rhea: RHEA:17873

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
H2OCHEBI:15377, H2O, cytosol
RCblCHEBI:140785, C62H88CoN13O14PR, cytosol

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
PiCHEBI:43474, HO4P, cytosol
RCblCHEBI:140785, C62H88CoN13O14PR, extracellular region

Catalysed by

ABC-type vitamin B12 transporter activity of ABCC1 [plasma membrane]EC 7.6.2.8; UniProt P33527

Literature

Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway Nat Rev Gastroenterol Hepatol, 2012
Investigation of the ABC transporter MRP1 in selected patients with presumed defects in vitamin B12 absorption Blood, 2011