MMACHC dealkylates RCbl
MMACHC + RCbl + GSH → R-GSH + MMACHC:cob(I)alamin + H+
- Reactome
- R-HSA-3095889
- Compartment
- cytosol
- Rhea
- RHEA:40720
Inputs
- MMACHCR-HSA-2980949, cytosol
- RCblCHEBI:140785, C62H88CoN13O14PR, cytosol
- GSHCHEBI:57925, C10H16N3O6S, cytosol
Outputs
- R-GSHCHEBI:90779, C10H15N3O6SR, cytosol
- MMACHC:cob(I)alaminR-HSA-9759561, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- transferase activity, transferring alkyl or aryl (other than methyl) groups of MMACHC [cytosol]EC 2.5; UniProt Q9Y4U1
Literature
- Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product Mol. Genet. Metab., 2009
- A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins J Biol Chem, 2009
- Structural basis of multifunctionality in a vitamin B12-processing enzyme J Biol Chem, 2011
- Identification of the gene responsible for methylmalonic aciduria and homocystinuria, cblC type Nat. Genet., 2006