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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CD320 binds extracellular TCN2:RCbl

CD320 + TCN2:RCbl → TCN2:RCbl:CD320

Reactome: R-HSA-3000122
Compartment: extracellular region · endosome membrane · endosome
Rhea: None recorded

Inputs

CD320R-HSA-2980909, plasma membrane
TCN2:RCblR-HSA-9759429, extracellular region

Outputs

TCN2:RCbl:CD320R-HSA-3000089, plasma membrane

Catalysed by

cargo receptor activity of CD320 [plasma membrane]UniProt Q9NPF0

Literature

The binding properties of the human receptor for the cellular uptake of vitamin B12 Biochem. Biophys. Res. Commun., 2005
The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin Blood, 2009
Positive newborn screen for methylmalonic aciduria identifies the first mutation in TCblR/CD320, the gene for cellular uptake of transcobalamin-bound vitamin B(12) Hum. Mutat., 2010