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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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CUBN:AMN binds CBLIF:RCbl

CBLIF:RCbl + CUBN:AMN → CUBN:AMN:CBLIF:RCbl

Reactome
R-HSA-3000103
Compartment
plasma membrane · extracellular region
Rhea
None recorded

Inputs

Outputs

Catalysed by

  • cargo receptor activity of CUBN:AMN [plasma membrane]

Literature

  1. Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution Proc. Natl. Acad. Sci. U.S.A., 2007
  2. The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless Blood, 2004
  3. Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes Nature, 2010
  4. Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1 Nat. Genet., 1999
  5. Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin Blood, 2000
  6. Structural assembly of the megadalton-sized receptor for intestinal vitamin B 12 uptake and kidney protein reabsorption Nat Commun, 2018