CUBN:AMN binds CBLIF:RCbl
CBLIF:RCbl + CUBN:AMN → CUBN:AMN:CBLIF:RCbl
- Reactome
- R-HSA-3000103
- Compartment
- plasma membrane · extracellular region
- Rhea
- None recorded
Inputs
- CBLIF:RCblR-HSA-3000147, extracellular region
- CUBN:AMNR-HSA-264830, plasma membrane
Outputs
- CUBN:AMN:CBLIF:RCblR-HSA-3000141, plasma membrane
Catalysed by
- cargo receptor activity of CUBN:AMN [plasma membrane]
Literature
- Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution Proc. Natl. Acad. Sci. U.S.A., 2007
- The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless Blood, 2004
- Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes Nature, 2010
- Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1 Nat. Genet., 1999
- Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin Blood, 2000
- Structural assembly of the megadalton-sized receptor for intestinal vitamin B 12 uptake and kidney protein reabsorption Nat Commun, 2018