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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

TCN2 binds RCbl in the circulation

TCN2 + RCbl → TCN2:RCbl

Reactome: R-HSA-3000074
Compartment: extracellular region
Rhea: None recorded

Inputs

TCN2R-HSA-2980925, extracellular region
RCblCHEBI:140785, C62H88CoN13O14PR, extracellular region

Outputs

TCN2:RCblR-HSA-9759429, extracellular region

Catalysed by

cargo receptor ligand activity of TCN2 [extracellular region]UniProt P20062

Literature

Structural basis of transcobalamin recognition by human CD320 receptor Nat Commun, 2016
Structure of the cDNA encoding transcobalamin I, a neutrophil granule protein J. Biol. Chem., 1989
Purification and molecular characterization of human transcobalamin II J. Biol. Chem., 1986
Structural basis for mammalian vitamin B12 transport by transcobalamin Proc. Natl. Acad. Sci. U.S.A., 2006