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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HLCS biotinylates PC:Mn2+

4x(PC:Mn2+) + 4 ATP + 4 Btn → 4x(Btn-PC:Mn2+) + 4 PPi + 4 AMP

Reactome: R-HSA-2993802
Compartment: cytosol
Rhea: None recorded

Inputs

4x(PC:Mn2+)R-HSA-2993798, cytosol
4 ATPCHEBI:30616, C10H12N5O13P3, cytosol
4 BtnCHEBI:15956, C10H16N2O3S, cytosol

Outputs

4x(Btn-PC:Mn2+)R-HSA-3323188, cytosol
4 PPiCHEBI:33019, HO7P2, cytosol
4 AMPCHEBI:456215, C10H12N5O7P, cytosol

Catalysed by

biotin--[biotin carboxyl-carrier protein] ligase activity of HLCS [cytosol]EC 6.3.4.10; UniProt P50747

Literature

Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction Nat. Struct. Mol. Biol., 2008
Mutations in the holocarboxylase synthetase gene HLCS Hum. Mutat., 2005
Holocarboxylase synthetase: correlation of protein localisation with biological function Arch. Biochem. Biophys., 2010
Identification of holocarboxylase synthetase (HCS) proteins in human placenta Biochim. Biophys. Acta, 1998
Selectivity in post-translational biotin addition to five human carboxylases J. Biol. Chem., 2012