FDXR transfers electrons to FDX1,2 (FDX1L)
FDXR:FADH2 + 2 FDX1,FDX2 (oxidized) → FDXR:FAD + 2 H+ + 2 FDX1,FDX2 (reduced)
- Reactome
- R-HSA-2395512
- Compartment
- mitochondrial matrix
- Rhea
- None recorded
Inputs
- FDXR:FADH2R-HSA-2395502, mitochondrial matrix
- 2 FDX1,FDX2 (oxidized)R-HSA-2408370, mitochondrial matrix
Outputs
- FDXR:FADR-HSA-2395508, mitochondrial matrix
- 2 H+CHEBI:15378, H, mitochondrial matrix
- 2 FDX1,FDX2 (reduced)R-HSA-2408372, mitochondrial matrix
Catalysed by
- ferredoxin-NADP+ reductase activity of FDXR [mitochondrial matrix]EC 1.18.1.2; UniProt P22570
Literature
- Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis Biochim. Biophys. Acta, 2012
- Humans possess two mitochondrial ferredoxins, Fdx1 and Fdx2, with distinct roles in steroidogenesis, heme, and Fe/S cluster biosynthesis Proc. Natl. Acad. Sci. U.S.A., 2010