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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PDSS1,2 ligates FPP to IPPP

FPP + 7 IPPP → all-E-10PrP2 + 7 PPi

Reactome: R-HSA-2162253
Compartment: mitochondrial matrix
Rhea: RHEA:27802, RHEA:27803

Inputs

FPPCHEBI:175763, C15H25O7P2, mitochondrial matrix
7 IPPPCHEBI:128769, C5H9O7P2, mitochondrial matrix

Outputs

all-E-10PrP2CHEBI:60721, C50H81O7P2, mitochondrial inner membrane
7 PPiCHEBI:33019, HO7P2, mitochondrial matrix

Catalysed by

all-trans-decaprenyl-diphosphate synthase activity of PDSS1/2 tetramer [mitochondrial matrix]EC 2.5.1.91

Literature

Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans FEBS J, 2005
Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells J Biochem Biophys Methods, 2008