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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC17A5 exports GlcA from the lysosome to the cytosol

GlcA + H+ → GlcA + H+

Reactome: R-HSA-2162229
Compartment: lysosomal membrane
Rhea: RHEA:72591

Inputs

GlcACHEBI:4178, C6H10O7, lysosomal lumen
H+CHEBI:15378, H, lysosomal lumen

Outputs

GlcACHEBI:58720, C6H9O7, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

glucuronate transmembrane transporter activity of SLC17A5 [lysosomal membrane]UniProt Q9NRA2

Literature

Hyaluronan catabolism: a new metabolic pathway Eur J Cell Biol, 2004
Devising a pathway for hyaluronan catabolism: are we there yet? Glycobiology, 2003
Functional characterization of wild-type and mutant human sialin EMBO J, 2004