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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GUSB tetramer hydrolyses (HA)2

H2O + (HA)2 → GlcA + GlcNAc-GlcA-GlcNAc

Reactome: R-HSA-2162227
Compartment: lysosomal lumen
Rhea: RHEA:17634

Inputs

H2OCHEBI:15377, H2O, lysosomal lumen
(HA)2R-ALL-2160866, lysosomal lumen

Outputs

GlcACHEBI:4178, C6H10O7, lysosomal lumen
GlcNAc-GlcA-GlcNAcR-ALL-2162223, lysosomal lumen

Catalysed by

beta-glucuronidase activity of GUSB tetramer [lysosomal lumen]EC 3.2.1.31

Literature

Cloning, sequencing, and expression of cDNA for human beta-glucuronidase Proc Natl Acad Sci U S A, 1987
A novel inhibitor of beta-glucuronidase: L-aspartic acid Pediatr Res, 2001