COQ7:COQ9 octamer hydroxylates DMQ10H2
DMQ10H2 + O2 + H+ + NADH → DeMQ10H2 + H2O + NAD+
- Reactome
- R-HSA-2162194
- Compartment
- mitochondrial inner membrane · mitochondrial matrix
- Rhea
- None recorded
Inputs
- DMQ10H2CHEBI:64181, C58H90O3, mitochondrial inner membrane
- O2CHEBI:15379, O2, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
- NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
Outputs
- DeMQ10H2CHEBI:64182, C58H90O4, mitochondrial inner membrane
- H2OCHEBI:15377, H2O, mitochondrial matrix
- NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
Catalysed by
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen of COQ3:COQ4…EC 1.14.13
Literature
- Conservation of the Caenorhabditis elegans timing gene clk-1 from yeast to human: a gene required for ubiquinone biosynthesis with potential implications for aging Mamm Genome, 1999
- The COQ7 gene encodes a protein in Saccharomyces cerevisiae necessary for ubiquinone biosynthesis J Biol Chem, 1996
- Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis J Biol Chem, 2006
- Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis Proc. Natl. Acad. Sci. U.S.A., 2014
- Structure and functionality of a multimeric human COQ7:COQ9 complex Mol Cell, 2022
- Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function Mol Cell, 2016