Unknown enzyme hydroxylates DMPhOH
DMPhOH + O2 + NADPH + H+ → MDMQ10H2 + NADP+ + H2O
- Reactome
- R-HSA-2162191
- Compartment
- mitochondrial matrix
- Rhea
- None recorded
Inputs
- DMPhOHCHEBI:50774, C57H88O2, mitochondrial inner membrane
- O2CHEBI:15379, O2, mitochondrial matrix
- NADPHCHEBI:57783, C21H26N7O17P3, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
Outputs
- MDMQ10H2CHEBI:64180, C57H88O3, mitochondrial inner membrane
- NADP+CHEBI:58349, C21H25N7O17P3, mitochondrial matrix
- H2OCHEBI:15377, H2O, mitochondrial matrix
Catalysed by
- monooxygenase activity of DMPhOH monooxygenase [mitochondrial matrix]
Literature
- Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency Chem Biol, 2011
- The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis J Biol Chem, 2003
- COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells bioRxiv, 2023
- In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis Nat Catal, 2024