ALOX5 oxidises 15S-HpETE to LXA4/B4
O2 + 2 15S-HpETE → 2 LXA4/B4
- Reactome
- R-HSA-2161917
- Compartment
- cytosol
- Rhea
- None recorded
Inputs
- O2CHEBI:15379, O2, cytosol
- 2 15S-HpETECHEBI:57446, C20H31O4, cytosol
Outputs
- 2 LXA4/B4R-ALL-2161856, cytosol
Catalysed by
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX5:ALOX5AP:LTC4S [nuclear envelope]EC 1.13.11
Literature
- Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes Proc Natl Acad Sci U S A, 1984
- Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes Biochem Biophys Res Commun, 1984
- Lipoxin synthesis by arachidonate 5-lipoxygenase purified from porcine leukocytes Biochem Biophys Res Commun, 1987
- Evidence for a 5(6)-epoxytetraene intermediate in the biosynthesis of lipoxins in human leukocytes. Conversion into lipoxin A by cytosolic epoxide hydrolase FEBS Lett, 1986