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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4

15R-HETE + O2 → 15epi-LXA4/B4

Reactome: R-HSA-2161907
Compartment: cytosol · nuclear envelope
Rhea: None recorded

Inputs

15R-HETECHEBI:78837, C20H31O3, cytosol
O2CHEBI:15379, O2, cytosol

Outputs

15epi-LXA4/B4R-ALL-2161609, cytosol

Catalysed by

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX5:ALOX5AP:LTC4S [nuclear envelope]EC 1.13.11

Literature

Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions Proc Natl Acad Sci U S A, 1995