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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALOX12 oxidises LTA4 to LXA4

2 LTA4 + O2 + 2 H2O → 2 LXA4

Reactome: R-HSA-2161775
Compartment: cytosol
Rhea: RHEA:48585

Inputs

2 LTA4CHEBI:57463, C20H29O3, cytosol
O2CHEBI:15379, O2, cytosol
2 H2OCHEBI:15377, H2O, cytosol

Outputs

2 LXA4CHEBI:67026, C20H31O5, cytosol

Catalysed by

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX12:Fe2+ [cytosol]EC 1.13.11

ALOX12 oxidises LTA4 to LXA4

Inputs

Outputs

Catalysed by

Literature