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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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Receptor-mediated uptake of HA

HA + HYAL2 + HARs → HA:HAR:HYAL2

Reactome
R-HSA-2160915
Compartment
plasma membrane · extracellular region
Rhea
None recorded

Inputs

Outputs

Catalysed by

  • cargo receptor activity of HARs [plasma membrane]

Literature

  1. The hyaluronate receptor is a member of the CD44 (H-CAM) family of cell surface glycoproteins J Cell Biol, 1990
  2. Hyaluronate binding and CD44 expression in human glioblastoma cells and astrocytes Exp Cell Res, 1992
  3. The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells J Cell Sci, 1998
  4. The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains Gene, 1996
  5. Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE) J Biol Chem, 2007
  6. The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin J Biol Chem, 2008