Receptor-mediated uptake of HA
HA + HYAL2 + HARs → HA:HAR:HYAL2
- Reactome
- R-HSA-2160915
- Compartment
- plasma membrane · extracellular region
- Rhea
- None recorded
Inputs
- HAR-ALL-2160848, extracellular region
- HYAL2R-HSA-2160919, plasma membrane
- HARsR-HSA-2160926, plasma membrane
Outputs
- HA:HAR:HYAL2R-HSA-2160889, plasma membrane
Catalysed by
- cargo receptor activity of HARs [plasma membrane]
Literature
- The hyaluronate receptor is a member of the CD44 (H-CAM) family of cell surface glycoproteins J Cell Biol, 1990
- Hyaluronate binding and CD44 expression in human glioblastoma cells and astrocytes Exp Cell Res, 1992
- The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells J Cell Sci, 1998
- The characterization of a human RHAMM cDNA: conservation of the hyaluronan-binding domains Gene, 1996
- Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE) J Biol Chem, 2007
- The human hyaluronan receptor for endocytosis (HARE/Stabilin-2) is a systemic clearance receptor for heparin J Biol Chem, 2008