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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HYAL2 hydrolyses HA into 20kDa fragments

HA:HAR:HYAL2 + H2O → (HA)50 + HAR:HYAL2

Reactome: R-HSA-2160892
Compartment: plasma membrane
Rhea: None recorded

Inputs

HA:HAR:HYAL2R-HSA-2160889, plasma membrane
H2OCHEBI:15377, H2O, cytosol

Outputs

(HA)50R-ALL-2160894, plasma membrane
HAR:HYAL2R-HSA-9954181, plasma membrane

Catalysed by

hyalurononglucosaminidase activity of HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane]EC 3.2.1.35

Literature

CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion J Biol Chem, 2004
Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis Proteins, 2005
HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity J Biol Chem, 1998
A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange Proc. Natl. Acad. Sci. U.S.A., 1996
Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1 J. Biol. Chem., 2007
Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements Biochemistry, 2004