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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HAS1,2,3 mediate the polymerization and export of HA

UDP-GlcA + UDP-GlcNAc → 2 H+ + 2 UDP + HA

Reactome: R-HSA-2160851
Compartment: plasma membrane · cytosol
Rhea: RHEA:12529, RHEA:20466

Inputs

UDP-GlcACHEBI:58052, C15H19N2O18P2, cytosol
UDP-GlcNAcCHEBI:57705, C17H25N3O17P2, cytosol

Outputs

2 H+CHEBI:15378, H, cytosol
2 UDPCHEBI:58223, C9H11N2O12P2, cytosol
HAR-ALL-2160848, extracellular region

Catalysed by

hyaluronan synthase activity of HAS1,2,3:Mg2+ [plasma membrane]EC 2.4.1.212

Literature

Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase J Biol Chem, 1997
Functional cloning of the cDNA for a human hyaluronan synthase J Biol Chem, 1996
Molecular identification of a putative human hyaluronan synthase J Biol Chem, 1996
Structure, substrate recognition and initiation of hyaluronan synthase Nature, 2022
Hyaluronan synthases; mechanisms, myths, & mysteries of three types of unique bifunctional glycosyltransferases Glycobiology, 2023
The hyaluronan synthase catalyzes the synthesis and membrane translocation of hyaluronan J Mol Biol, 2012