Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate

HS(2)-PGs + PAPS → PAP + HS(3)-PGs + H+

Reactome: R-HSA-2076508
Compartment: Golgi membrane · Golgi lumen
Rhea: None recorded

Inputs

HS(2)-PGsR-HSA-2076425, Golgi lumen
PAPSCHEBI:58339, C10H11N5O13P2S, Golgi lumen

Outputs

PAPCHEBI:58343, C10H11N5O10P2, Golgi lumen
HS(3)-PGsR-HSA-2076297, Golgi lumen
H+CHEBI:15378, H, Golgi lumen

Catalysed by

heparan sulfate 2-sulfotransferase activity of HS2ST1 trimer [Golgi membrane]EC 2.8.2

HS2ST1 trimer sulfates IdoA at C2 in heparan sulfate

Inputs

Outputs

Catalysed by

Literature