HS6STs sulfate GlcN at C6 in heparan sulfate/heparin
HS(5)-PGs + PAPS → PAP + HS/HPIN-PGs + H+
- Reactome
- R-HSA-2076419
- Compartment
- Golgi membrane · Golgi lumen
- Rhea
- RHEA:56605
Inputs
- HS(5)-PGsR-HSA-2076461, Golgi lumen
- PAPSCHEBI:58339, C10H11N5O13P2S, Golgi lumen
Outputs
- PAPCHEBI:58343, C10H11N5O10P2, Golgi lumen
- HS/HPIN-PGsR-HSA-2076357, Golgi lumen
- H+CHEBI:15378, H, Golgi lumen
Catalysed by
- heparan sulfate 6-sulfotransferase activity of HS6STs [Golgi membrane]EC 2.8.2
Literature
- Molecular characterization and expression of heparan-sulfate 6-sulfotransferase. Complete cDNA cloning in human and partial cloning in Chinese hamster ovary cells J Biol Chem, 1998
- Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties Biochem J, 2003
- The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine J Biol Chem, 2000
- Heparan sulfate 6-O-sulfotransferase 1, a gene involved in extracellular sugar modifications, is mutated in patients with idiopathic hypogonadotrophic hypogonadism Proc Natl Acad Sci U S A, 2011
- A HS6ST2 gene variant associated with X-linked intellectual disability and severe myopia in two male twins Clin Genet, 2019