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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HS3ST1 sulfates GlcN at C3 in heparan sulfate

HS(3)-PGs + PAPS → PAP + HS(4)-PGs + H+

Reactome: R-HSA-2076383
Compartment: Golgi lumen
Rhea: RHEA:15462

Inputs

HS(3)-PGsR-HSA-2076297, Golgi lumen
PAPSCHEBI:58339, C10H11N5O13P2S, Golgi lumen

Outputs

PAPCHEBI:58343, C10H11N5O10P2, Golgi lumen
HS(4)-PGsR-HSA-2076491, Golgi lumen
H+CHEBI:15378, H, Golgi lumen

Catalysed by

[heparan sulfate]-glucosamine 3-sulfotransferase activity of HS3ST1 [Golgi lumen]EC 2.8.2.23; UniProt O14792

Literature

Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase J Biol Chem, 1997