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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ST3GAL1-4,6 optionally cap keratan chain

Keratan(3)-PG + CMP-Neu5Ac → CMP + Keratan(4)-PG + H+

Reactome: R-HSA-2046285
Compartment: Golgi membrane · Golgi lumen
Rhea: RHEA:52317

Inputs

Keratan(3)-PGR-HSA-2046314, Golgi lumen
CMP-Neu5AcCHEBI:57812, C20H29N4O16P, Golgi lumen

Outputs

CMPCHEBI:60377, C9H12N3O8P, Golgi lumen
Keratan(4)-PGR-HSA-2046203, Golgi lumen
H+CHEBI:15378, H, Golgi lumen

Catalysed by

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity of ST3GAL1-4,6 [Golgi membrane]EC 2.4.3.4

Literature

Characterization of two glycolipid: alpha 2-3sialyltransferases, SAT-3 (CMP-NeuAc:nLcOse4Cer alpha 2-3sialyltransferase) and SAT-4 (CMP-NeuAc:GgOse4Cer alpha 2-3sialyltransferase), from human colon carcinoma (Colo 205) cell line Biochemistry, 1996
Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase Biochem Biophys Res Commun, 1993
Molecular cloning and expression of Galbeta1,3GalNAc alpha2, 3-sialyltransferase from human fetal liver Eur J Biochem, 1999
Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II) Biochem Biophys Res Commun, 1996
Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids J Biol Chem, 1999