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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CHST2,3,5,6 transfer sulfate to GlcNAc on keratan chain

Keratan(4)-PG + PAPS → PAP + KSPG(1) + H+

Reactome: R-HSA-2046222
Compartment: Golgi membrane · Golgi lumen
Rhea: RHEA:67857

Inputs

Keratan(4)-PGR-HSA-2046203, Golgi lumen
PAPSCHEBI:58339, C10H11N5O13P2S, Golgi lumen

Outputs

PAPCHEBI:58343, C10H11N5O10P2, Golgi lumen
KSPG(1)R-HSA-2046166, Golgi lumen
H+CHEBI:15378, H, Golgi lumen

Catalysed by

N-acetylglucosamine 6-O-sulfotransferase activity of CHST2,3,5,6 [Golgi membrane]EC 2.8.2

Literature

Functional expression and genomic structure of human N-acetylglucosamine-6-O-sulfotransferase that transfers sulfate to beta-N-acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence Biochim Biophys Acta, 2000
Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue Biochem Biophys Res Commun, 1999
Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate J Biol Chem, 2002