B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG
UDP-GlcNAc + Gal-glycan-protein → UDP + Keratan(1)-PG + H+
- Reactome
- R-HSA-2025724
- Compartment
- Golgi membrane · Golgi lumen
- Rhea
- RHEA:14390
Inputs
- UDP-GlcNAcCHEBI:57705, C17H25N3O17P2, Golgi lumen
- Gal-glycan-proteinR-HSA-2046271, Golgi lumen
Outputs
- UDPCHEBI:58223, C9H11N2O12P2, Golgi lumen
- Keratan(1)-PGR-HSA-2046187, Golgi lumen
- H+CHEBI:15378, H, Golgi lumen
Catalysed by
- N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity of B3GNT1,2,3,4,7 [Golgi membrane]EC 2.4.1.149
Literature
- Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family J Biol Chem, 2001
- Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains J Biol Chem, 1998
- Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide beta 1,3-N-acetylglucosaminyltransferase (beta 3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids J Biol Chem, 2001
- Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans J Biol Chem, 2002
- Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family Glycoconj J, 2004
- A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer FEBS Lett, 2005