B4GALTs transfer Gal to the N-glycan precursor
UDP-Gal + N-glycan-protein → UDP + Gal-glycan-protein + H+
- Reactome
- R-HSA-2025723
- Compartment
- Golgi membrane · Golgi lumen
- Rhea
- RHEA:22933
Inputs
- UDP-GalCHEBI:66914, C15H22N2O17P2, Golgi lumen
- N-glycan-proteinR-HSA-2046280, Golgi lumen
Outputs
- UDPCHEBI:58223, C9H11N2O12P2, Golgi lumen
- Gal-glycan-proteinR-HSA-2046271, Golgi lumen
- H+CHEBI:15378, H, Golgi lumen
Catalysed by
- beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity of B4GALT1-6 homodimers [Golgi membrane]EC 2.4.1.38
Literature
- Galactosylation of N-linked oligosaccharides by human beta-1,4-galactosyltransferases I, II, III, IV, V, and VI expressed in Sf-9 cells Glycobiology, 2001
- The expanding beta 4-galactosyltransferase gene family: messages from the databanks Glycobiology, 1998
- Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId J Clin Invest, 2002
- Evidence for a molecular distinction between Golgi and cell surface forms of beta 1,4-galactosyltransferase J Biol Chem, 1991
- Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated Mol Biol Cell, 2006
- Exploiting Substrate Specificities of 6- O -Sulfotransferases to Enzymatically Synthesize Keratan Sulfate Oligosaccharides JACS Au, 2023