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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap
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GLCE epimerises GlcA to IdoA

HS(1)-PGs → HS(2)-PGs

Reactome
R-HSA-2024100
Compartment
Golgi membrane · Golgi lumen
Rhea
RHEA:20198

Inputs

Outputs

Catalysed by

  • heparosan-N-sulfate-glucuronate 5-epimerase activity of GLCE dimer [Golgi membrane]EC 5.1.3.17

Literature

  1. Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate J Biol Chem, 2001
  2. Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase J Biol Chem, 2001