NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)
2 PAPS + Heparan(4)-PGs → 2 PAP + HS(1)-PGs + H+
- Reactome
- R-HSA-2022860
- Compartment
- Golgi membrane · Golgi lumen
- Rhea
- RHEA:21981
Inputs
- 2 PAPSCHEBI:58339, C10H11N5O13P2S, Golgi lumen
- Heparan(4)-PGsR-HSA-2076346, Golgi lumen
Outputs
- 2 PAPCHEBI:58343, C10H11N5O10P2, Golgi lumen
- HS(1)-PGsR-HSA-2076452, Golgi lumen
- H+CHEBI:15378, H, Golgi lumen
Catalysed by
- heparan sulfate N-sulfotransferase activity of NDSTs [Golgi membrane]EC 2.8.2.8
Literature
- Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2 Biochem Biophys Res Commun, 2006
- Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1 Genomics, 1995
- Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family J Biol Chem, 1999
- Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4 J Biol Chem, 2001