CHST14 transfers SO4(2-) to GalNAc in dermatan or DS
CHST14 substrates + PAPS → PAP + CHST14 products + H+
- Reactome
- R-HSA-2022063
- Compartment
- Golgi membrane · Golgi lumen
- Rhea
- RHEA:48053
Inputs
- CHST14 substratesR-HSA-5607518, Golgi lumen
- PAPSCHEBI:58339, C10H11N5O13P2S, Golgi lumen
Outputs
- PAPCHEBI:58343, C10H11N5O10P2, Golgi lumen
- CHST14 productsR-HSA-5607524, Golgi lumen
- H+CHEBI:15378, H, Golgi lumen
Catalysed by
- dermatan 4-sulfotransferase activity of CHST14 [Golgi membrane]EC 2.8.2.35; UniProt Q8NCH0
Literature
- Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate Glycobiology, 2009
- Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase J. Biol. Chem., 2001
- Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome Hum. Mutat., 2010