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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Dermatan sulfate can be further sulfated on position 2 of iduronate

D4S-PGs + PAPS → PAP + D2,4(S)2-PG + H+

Reactome: R-HSA-2022061
Compartment: Golgi membrane · Golgi lumen
Rhea: None recorded

Inputs

D4S-PGsR-HSA-2065135, Golgi lumen
PAPSCHEBI:58339, C10H11N5O13P2S, Golgi lumen

Outputs

PAPCHEBI:58343, C10H11N5O10P2, Golgi lumen
D2,4(S)2-PGR-HSA-2065145, Golgi lumen
H+CHEBI:15378, H, Golgi lumen

Catalysed by

sulfotransferase activity of UST [Golgi membrane]EC 2.8.2; UniProt Q9Y2C2

Literature

Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate J Biol Chem, 1999