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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DSE converts GlcA to IdoA

DSE,DSEL substrates → DSE,DSEL products

Reactome: R-HSA-2022052
Compartment: Golgi membrane · Golgi lumen
Rhea: RHEA:21085

Inputs

DSE,DSEL substratesR-HSA-5607547, Golgi lumen

Outputs

DSE,DSEL productsR-HSA-5607545, Golgi lumen

Catalysed by

chondroitin-glucuronate 5-epimerase activity of DSE,DSEL [Golgi membrane]EC 5.1.3.19

Literature

Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2 J Biol Chem, 2006
The glucuronyl C5-epimerase activity is the limiting factor in the dermatan sulfate biosynthesis Arch Biochem Biophys, 2001
A novel CpG-associated brain-expressed candidate gene for chromosome 18q-linked bipolar disorder Mol. Psychiatry, 2003
Two dermatan sulfate epimerases form iduronic acid domains in dermatan sulfate J. Biol. Chem., 2009
Loss of dermatan sulfate epimerase (DSE) function results in musculocontractural Ehlers-Danlos syndrome Hum Mol Genet, 2013