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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains

chondroitin(3)-core proteins + PAPS → PAP + C6S-PG + H+

Reactome: R-HSA-2018682
Compartment: Golgi membrane · Golgi lumen
Rhea: RHEA:11109

Inputs

chondroitin(3)-core proteinsR-HSA-2064075, Golgi lumen
PAPSCHEBI:58339, C10H11N5O13P2S, Golgi lumen

Outputs

PAPCHEBI:58343, C10H11N5O10P2, Golgi lumen
C6S-PGR-HSA-2064219, Golgi lumen
H+CHEBI:15378, H, Golgi lumen

Catalysed by

chondroitin 6-sulfotransferase activity of CHST3,7 [Golgi membrane]EC 2.8.2.17

Literature

Functional expression and genomic structure of human chondroitin 6-sulfotransferase FEBS Lett, 1998
Molecular cloning and expression of a novel chondroitin 6-O-sulfotransferase J Biol Chem, 2000