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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD

NAMN + ATP + H+ → NAAD + PPi

Reactome: R-HSA-200512
Compartment: nucleoplasm
Rhea: RHEA:22861, RHEA:21361

Inputs

NAMNCHEBI:57502, C11H12NO9P, nucleoplasm
ATPCHEBI:30616, C10H12N5O13P3, nucleoplasm
H+CHEBI:15378, H, nucleoplasm

Outputs

NAADCHEBI:58437, C21H24N6O15P2, nucleoplasm
PPiCHEBI:33019, HO7P2, nucleoplasm

Catalysed by

nicotinate-nucleotide adenylyltransferase activity of 6xNMNAT1:6xZn2+ [nucleoplasm]EC 2.7.7.18

Literature