NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD
NAMN + ATP + H+ → NAAD + PPi
- Reactome
- R-HSA-200474
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:22861, RHEA:21361
Inputs
- NAMNCHEBI:57502, C11H12NO9P, mitochondrial matrix
- ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
Outputs
- NAADCHEBI:58437, C21H24N6O15P2, mitochondrial matrix
- PPiCHEBI:33019, HO7P2, mitochondrial matrix
Catalysed by
- nicotinate-nucleotide adenylyltransferase activity of 4xNMNAT3:4xMg2+ [mitochondrial matrix]EC 2.7.7.18
Literature
- Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms J Biol Chem, 2005
- Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis Biochemistry, 2007
- Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis J Biol Chem, 2003