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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC19A2/3 transport extracellular THMN to cytosol

THMN → THMN

Reactome: R-HSA-199626
Compartment: plasma membrane
Rhea: RHEA:34919

Inputs

THMNCHEBI:18385, C12H17N4OS, extracellular region

Outputs

THMNCHEBI:18385, C12H17N4OS, cytosol

Catalysed by

thiamine transmembrane transporter activity of SLC19A2/3 [plasma membrane]

Literature

Thiamin uptake by the human-derived renal epithelial (HEK-293) cells: cellular and molecular mechanisms Am J Physiol Renal Physiol, 2006
Mutations in a new gene encoding a thiamine transporter cause thiamine-responsive megaloblastic anaemia syndrome Nat Genet, 1999
The gene mutated in thiamine-responsive anaemia with diabetes and deafness (TRMA) encodes a functional thiamine transporter Nat Genet, 1999
Mutations in SLC19A2 cause thiamine-responsive megaloblastic anaemia associated with diabetes mellitus and deafness Nat Genet, 1999
Expression and functional contribution of hTHTR-2 in thiamin absorption in human intestine Am J Physiol Gastrointest Liver Physiol, 2004
Targeting and trafficking of the human thiamine transporter-2 in epithelial cells J Biol Chem, 2006