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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol

Btn + 2 Na+ → Btn + 2 Na+

Reactome: R-HSA-199219
Compartment: plasma membrane
Rhea: RHEA:73375

Inputs

BtnCHEBI:15956, C10H16N2O3S, extracellular region
2 Na+CHEBI:29101, Na, extracellular region

Outputs

BtnCHEBI:15956, C10H16N2O3S, cytosol
2 Na+CHEBI:29101, Na, cytosol

Catalysed by

sodium-dependent multivitamin transmembrane transporter activity of SLC5A6:PDZD11 [plasma membrane]

Literature

Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization. J Biol Chem, 1999
Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter Arch Biochem Biophys, 1999
Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system Am. J. Physiol. Gastrointest. Liver Physiol., 2003
Association of PDZ-containing protein PDZD11 with the human sodium-dependent multivitamin transporter Am. J. Physiol. Gastrointest. Liver Physiol., 2011