Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix

CoA-SH → CoA-SH

Reactome: R-HSA-199216
Compartment: mitochondrial inner membrane
Rhea: None recorded

Inputs

CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Outputs

CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Catalysed by

coenzyme A transmembrane transporter activity of SLC25A16 [mitochondrial inner membrane]UniProt P16260

Literature

Activation of human mitochondrial pantothenate kinase 2 by palmitoylcarnitine Proc Natl Acad Sci U S A, 2007
The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix Mol Cell Biol, 2001
Regulation of coenzyme A levels by degradation: the 'Ins and Outs' Prog Lipid Res, 2020