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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PANK1/3 phosphorylate PanK

PanK + ATP → PPanK + ADP + H+

Reactome: R-HSA-199203
Compartment: cytosol
Rhea: RHEA:16374

Inputs

PanKCHEBI:29032, C9H16NO5, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

PPanKCHEBI:10986, C9H15NO8P, cytosol
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

pantothenate kinase activity of PANK1/3 [cytosol]EC 2.7.1.33

Literature

Inherited Disorders of Coenzyme A Biosynthesis: Models, Mechanisms, and Treatments Int J Mol Sci, 2023
Coenzyme A: back in action Prog Lipid Res, 2005
PPARalpha controls the intracellular coenzyme A concentration via regulation of PANK1alpha gene expression J Lipid Res, 2004
The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes Gene, 2002
A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome Nat Genet, 2001